# Dr. C. Anbarasi - Research Officer (Siddha) & Clinical Researcher Source: https://hello.cv/natarajanshanmugasundaram Chennai ## Links - LinkedIn | https://in.linkedin.com/in/anbarasi-chandrasekaran ## About Highly accomplished Research Officer (Siddha) with over a decade of experience in clinical research, specializing in traditional medicine, pharmacology, and public health. Proven expertise in leading and co-investigating complex research projects, particularly in diabetes and musculoskeletal disorders, resulting in two granted patents and numerous high-impact publications. Drives scientific advancement and innovation in Siddha medicine through rigorous study design, data analysis, and strategic project management. ## Work ### Research Officer (Siddha) | Siddha Central Research Institute Currently leads research initiatives within the Varmam, Thokkanam & Traditional Bone Setting Division, advancing Siddha medicine through rigorous clinical trials and innovative project development. - Led the development and evaluation of 'SIDKAD,' a Siddha Kayakarpam diet for diabetes, assessing its nutritive, anti-oxidant, and anti-inflammatory properties. - Directed preclinical and clinical studies on Siddha polyherbal formulations, including Madhumega chooranam (MMC), culminating in a PhD study on its pharmacokinetic profile. - Spearheaded the mapping of Varmam points on a 3D virtual body and developed a personalized virtual body simulator, integrating traditional knowledge with modern technology. - Managed a single-center randomized parallel group clinical trial comparing Siddha Varmam Therapy and Tailam therapy for Kumbavatham (Adhesive capsulitis), demonstrating efficacy in pain and disability reduction. - Conducted multiple prospective, single-center, randomized open-label clinical studies to evaluate Siddha medicine efficacy (Kabasura Kudineer with vitamin C-zinc) in managing asymptomatic COVID-19 patients across various medical colleges. - Authored and co-authored over 20 publications in peer-reviewed journals, contributing significantly to the scientific literature on Siddha medicine and traditional therapies. ### Research Associate (Siddha) | Sri Ramachandra University Contributed to the DST-funded PURSE HIS Cohort Study, focusing on cardiovascular health and risk factors within diverse Indian populations, and supported various research projects in Siddha medicine. - Contributed to the DST-funded PURSE HIS Cohort Study, analyzing data on vascular stiffness and coronary artery disease risk factors across urban, rural, and semi-urban populations. - Authored or co-authored multiple research papers published in journals such as Journal of Complementary Medicine Research and Indian Heart Journal, based on cohort study findings. - Participated in studies evaluating the efficacy and safety of Siddha formulations, including Madhumega chooranam, contributing to pharmacological and clinical research insights. ### Medical Officer (Siddha) | Sri Ramachandra Medical College and Research Institute Provided direct patient care and consultations in the AYUSH Out-Patient Department, applying Siddha medical principles and managing various health conditions. - Provided comprehensive Siddha medical consultations and treatment to patients in the AYUSH OPD, ensuring effective patient management. - Applied in-depth knowledge of Siddha therapies to treat diverse conditions, contributing to improved patient outcomes and well-being. ### Lecturer (Siddha) | Velumailu Siddha Medical College Delivered academic instruction in Siddha medicine, preparing future practitioners through comprehensive teaching and curriculum development. - Instructed students on foundational and advanced Siddha medical principles and practices, fostering academic and clinical understanding. - Developed and delivered engaging curriculum content for various Siddha courses, ensuring adherence to educational standards and promoting student learning. ## Education ### Sri Ramachandra Institute for Higher Education and Research | Pharmacokinetics of Siddha Formulations ### Government Siddha Medical College | Siddha Medicine ### Government Siddha Medical College | Siddha Medicine and Surgery ## Awards ### Indian Patent Grant Government of India | 2022-02-15 Awarded Patent No: 414681, further validating contributions to novel Siddha formulations and therapeutic approaches. ### Indian Patent Grant Government of India | 2021-02-22 Awarded Patent No: 359036, recognizing significant innovation in Siddha medicine and therapy. ### Finalist in CCRS Logo Competition Central Council for Research in Siddha | 2015-09-19 Recognized as a finalist in the national logo design competition, showcasing engagement with institutional branding initiatives. ### International Travel Grant for Young Scientist Department of Science and Technology, Government of India | 2011-03-01 Received a prestigious grant to present research at the 10th Annual Oxford Conference on Science of Botanicals in Oxford, Mississippi, USA. ## Publications ### Yakopu Vaithiya Cinthamani 700 (English Translation) Provided an English translation of the classic Siddha book 'Yakopu Vaithiya Cinthamani 700', making traditional knowledge accessible to a wider audience. ### Siddha COVID Care Centers in Tamil Nadu, India: Coverage, Workload, and Knowledge Gaps Cureus Analyzed the coverage, workload, and knowledge gaps within Siddha COVID Care Centers across Tamil Nadu, India, providing critical insights for public health strategy. ### Pharmacokinetics of Siddha Antidiabetic Polyherbal Formulation Madhumega Chooranam in Healthy Volunteers Cureus Investigated the pharmacokinetic profile of the Siddha polyherbal formulation Madhumega Chooranam in healthy volunteers, contributing to understanding its absorption, distribution, metabolism, and excretion. ### Clinical profile of the patients at Siddha Covid Care Centre, Theni, Tamil Nadu, India: A cross sectional study J Family Med Prim Care Conducted a cross-sectional study on the clinical profiles of patients at a Siddha COVID Care Centre in Theni, Tamil Nadu, providing data on patient demographics and disease characteristics. ### Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, India. Trials Demonstrated the efficacy of Kabasura Kudineer in reducing SARS-CoV-2 viral load in asymptomatic COVID-19 patients compared to standard supplementation. ### SiddhaVarmam and Thokkanam therapy (SVT) in the treatment of adhesive capsulitis (Kumbavatham) - A case study J Ayurveda Integr Med Presented a case study on the successful treatment of adhesive capsulitis (Kumbavatham) using Siddha Varmam and Thokkanam therapy. ### Comorbidity profile of Siddha Varmam therapy patients and insight into integrative pain management: A cross sectional study J Complement Med Res Investigated the comorbidity profiles of patients undergoing Siddha Varmam therapy, providing insights into integrative pain management approaches. ### Efficacy of Integrative Siddha Medicine, Kabasura Kudineer with Vitamin C, Zinc Supplementation for the Management of Asymptomatic COVID 19 Cases in Tertiary Hospital: A Randomized Controlled Trial J Complement Med Res Conducted a randomized controlled trial to assess the efficacy of integrative Siddha medicine (Kabasura Kudineer with Vitamin C, Zinc) in managing asymptomatic COVID-19 cases in a tertiary hospital setting. ### COVID-19-specific clinical research using traditional medicine: lessons from traditional Chinese medicine for India's AYUSH systems. Current Science Explored lessons from traditional Chinese medicine's approach to COVID-19 research, providing insights for India's AYUSH systems. ### Home Care Preventive Measures And Practices Using Traditional Siddha Medicine Towards COVID-19 Among Residents Of Containment Zones, Chennai, Tamil Nadu, India, 2020: Cross-Sectional Study J Complement Med Res Explored the adoption and effectiveness of traditional Siddha medicine in home care preventive measures among residents in COVID-19 containment zones in Chennai. ### The efficacy of Siddha Medicine, Kabasura Kudineer (KSK) compared to Vitamin C & Zinc (CZ) supplementation in the management of asymptomatic COVID-19 cases: A structured summary of a study protocol for a randomised controlled trial. Trials Outlined the study protocol for a randomized controlled trial comparing Kabasura Kudineer to Vitamin C & Zinc supplementation for asymptomatic COVID-19 management. ### Work Title: Guidelines for Practice of Siddha Varmam Therapy (Book) Central Council for Research in Siddha Secured copyright for the book 'Guidelines for Practice of Siddha Varmam Therapy', a key resource in the field. ### Treatment of acute avulsion of posterior cruciate ligament of left knee with bony fragment by Siddha Varmam therapy and traditional bone setting method. Journal of Ayurveda and integrative medicine Documented a case study on the successful treatment of acute posterior cruciate ligament avulsion using Siddha Varmam therapy and traditional bone setting. ### Antioxidant activities of Siddha polyherbal formulation Madhumega Chooranam (MMC) using in vitro assay models. WJPR Evaluated the antioxidant activities of Madhumega Chooranam using in vitro assay models, demonstrating its therapeutic potential. ### A hospital based cross sectional study on the prevalence of musculoskeletal diseases in Varmam out-patient department, Siddha Central Research Institute, Chennai. Journal of Indian medicine and Homeopathy Determined the prevalence of musculoskeletal diseases among patients attending the Varmam outpatient department at Siddha Central Research Institute in Chennai. ### Phytochemical screening and pharmacognostic evaluation of the Siddha poly herbal formulation Madhumega chooranam. Journal of Pharmacognosy and Phytochemistry Conducted phytochemical screening and pharmacognostic evaluation of Madhumega chooranam, detailing its herbal composition and properties. ### Urbanization as a risk factor for aortic stiffness in a cohort in India. PloS one Identified urbanization as a significant risk factor for aortic stiffness in an Indian cohort, contributing to cardiovascular health research. ### Guidelines for Practice of Siddha Varmam Therapy DCR, LRDD, SCRI, Central Council for Research in Siddha Co-authored a comprehensive guide establishing best practices for Siddha Varmam Therapy. ### Effect of Varmam Therapy in Santhu Vatham (Osteo Arthritis-Knee Joint)-A Single Case Study. International Journal of Pharmacy and Pharmaceutical Sciences Presented a single case study demonstrating the positive effects of Varmam Therapy in treating Santhu Vatham (Osteo Arthritis-Knee Joint). ### Siddha Protocol and outcomes (SPROUT) for Siddha External Therapies DCR, LRDD, SCRI, Central Council for Research in Siddha Contributed to a publication outlining protocols and expected outcomes for Siddha external therapies. ### Vascular aging in healthy population of both sexes in 3 strata of South Indian population. Indian Heart Journal Analyzed vascular aging in healthy populations across various regions of South India, providing insights into cardiovascular health trends. ### Population study of urban, rural, and semiurban regions for the detection of endovascular disease and prevalence of risk factors and holistic intervention study: rationale, study design, and baseline characteristics of PURSE-HIS. Global heart Described the rationale, study design, and baseline characteristics of the PURSE-HIS study, investigating endovascular disease and risk factors across different Indian regions. ### Nandukkal, a fossil crab used in Siddha Medicine and its therapeutic usage-a review. Malaya Journal of Biosciences (MJB) Provided a comprehensive review of Nandukkal (fossil crab) in Siddha Medicine, detailing its therapeutic applications and traditional usage. ### Vascular stiffness in both men and women with more than 3 risk factors from urban, semi-urban and rural areas of South India. Indian Heart Journal Investigated vascular stiffness in men and women with multiple risk factors across urban, semi-urban, and rural areas of South India. ### Population study of urban, rural and semi-urban regions to assess the prevalence of risk factors conducive to endovascular disease and its incidence for holistic intervention-PURSE HIS Cohort Study. Indian Heart Journal Assessed the prevalence and incidence of risk factors for endovascular disease in a population study spanning urban, rural, and semi-urban regions. ### Venthamarai chooranam, a polyherbal Siddha medicine, alleviates hypertension via AT1R and eNOS signaling pathway in 2K1C hypertensive rats. Experimental Biology and Medicine Demonstrated that Venthamarai chooranam, a Siddha polyherbal medicine, alleviates hypertension by modulating AT1R and eNOS signaling pathways in hypertensive rat models. ### Efficacy and Safety Profile of Siddha Compound Madhumega choornam (MMC) in Type II Diabetic Patients. International Journal for Pharmaceutical Research Scholars Evaluated the efficacy and safety profile of Madhumega choornam (MMC) in patients with Type II Diabetes Mellitus. ### Polyphenols in madhumega chooranam, a Siddha medicine, ameliorates carbohydrate metabolism and oxidative stress in type II diabetic rats. Journal of ethnopharmacology Demonstrated that polyphenols present in Madhumega chooranam ameliorate carbohydrate metabolism and oxidative stress in type II diabetic rat models. ### Prevalence of vascular stiffness, a marker of future vascular events in age matched population in normal population versus hypertension population and diabetic population. CIRCULATION Investigated the prevalence of vascular stiffness across normal, hypertensive, and diabetic populations, identifying it as a marker for future vascular events. ### Prevalence of risk factors for coronary artery disease in middle income group in South Indian population. Circ Assessed the prevalence of coronary artery disease risk factors within the middle-income group in the South Indian population. ### A Comprehensive study on a polyherbal Siddha Compound on Plasma Glucose and Serum Lipids in South Indian Population. Planta Medica, Journal of Medicinal Plant and Natural Product Research Conducted a comprehensive study on the effects of a polyherbal Siddha compound on plasma glucose and serum lipids in the South Indian population. ## Languages - English - Tamil ## Certificates ### Diploma in Biostatistics & Research Methodology ### Fundamentals of Clinical Trials Harvard School of Public Health, USA ### Good Clinical Practice - CITI Program Sri Ramachandra University and University of MIAMI ### Health Systems Strengthening Indian Institute of Public Health, Gandhinagar ### Ethical issues in Health research in India SCTIMST, Thiruvananthapuram ### Gender Women and Health Indian Institute of Public Health, Gandhinagar ### Yoga Instructor Course SVYASA, Bangalore ### Professional Training Programme in Patent Law & Practice Institute of Patent Attorneys, India (A unit of Intellectual Property, Research Institute), New Delhi ### Certificate Course on Effective Patent Drafting (PAT DRAFT - 2019) Centre for Intellectual Property Rights (CIPR), Anna University, Chennai ## Skills ### Public Health & Education - Health Systems Strengthening - Public Health Initiatives - Medical Education - Curriculum Development - Patient Care - Yoga Instruction ### Research & Development - Clinical Research - Research Methodology - Biostatistics - Clinical Trials - Pharmacokinetics - Study Design - Data Analysis - Epidemiology - Problem Solving - Scientific Writing - Grant Writing ### Traditional Medicine - Siddha Medicine - Varmam Therapy - Thokkanam - Traditional Bone Setting - AYUSH Systems - Herbal Formulations - Siddha Clinical Practice ### Project Management - Project Leadership - Team Leadership - Cross-functional Collaboration - Stakeholder Management - Project Coordination - Strategic Planning ### Intellectual Property - Patent Law - Patent Drafting - Intellectual Property Rights - Copyright Management ## Projects ### Development of Health Flakes (SIDKAD) Led the development of SIDKAD, a Siddha Kayakarpam diet for diabetes, and conducted evaluations of its nutritive, anti-oxidant, and anti-inflammatory activity. ### Evaluation of Varma Kanji Formulations Conducted studies to evaluate the anti-inflammatory, analgesic activity, and acute toxicity for Varma kanji V7 and V9 formulations in rat models. ### 3D Virtual Body Mapping of Varmam Points Co-investigated the mapping of Varmam points on a 3D virtual body and the development of a personalized virtual body simulator. ### Clinical Trial on Siddha Varmam Therapy for Kumbavatham Co-investigated a single-center randomized parallel group clinical trial comparing the efficacy of Siddha Varmam Therapy and Tailam therapy versus Tailam therapy alone for pain and disability in Kumbavatham (Adhesive capsulitis). ### Pharmacokinetic Study of Madhumega Chooranam (MMC) Conducted a comprehensive pharmacokinetic study on the Siddha polyherbal formulation, Madhumega chooranam (MMC), across preclinical and clinical settings as part of PhD research. ## Source Read this profile on Hello.cv: https://hello.cv/natarajanshanmugasundaram Create your free profile at https://hello.cv